Model-based methods

In many systems biology applications prior knowledge exists as to the nature of the biology underlying the collected data. This knowledge can be formalized in models of different nature and - ideally - these models describe the essential biological processes in a concise way. Such models can range from first-principles biochemical models, to agent-based models and grey models.

Lumped systems biology model of the fate of polyphenols in the human body as used in Nutrikinetics studies (from the thesis of Ewoud van Velzen).