Vacancies

The BDA group has the following positions available. For more information, contact A.K. Smilde ( ) .

A knowledge base of polyphenol degradation routes in humans using concept maps will be build. Based on this, systems biology models will be made. Finally, validating the knowledge base using systems biology model results will be explored.
Protein-protein interaction networks of the protein makeup of synapses in the brain will be build. From these networks, methods to predict new protein complexes have to be developed.
Grey modeling methodology will be developed that combines data driven models and prior information to build systems biology models. The main research questions are how to incorporate various types of prior knowledge in these models and how to validate the grey models.

As part of the systems bioinformatics project the scientific programmer will work on the BioExpert project. The overall aim of the BioExpert project is to develop a framework to represent, integrate and present (curated) knowledge of specific biological systems and to use this information in subsequent modelling applications. The overall framework is based on state-of-the-art approaches for Information Management (e.g., RDF/OWL) and novel approaches for information (re)presentation (i.e., concept map network). The BioExpert knowledge base stores conceptual models that provide a comprehensive, accurate, and up-to-date description of selected biological systems to serve as input for mathematical modeling.